Marinate the chicken drumsticks in buttermilk for at least 1 hour.
In a bowl, combine flour, paprika, garlic powder, onion powder, salt, and pepper.
Remove chicken from the buttermilk and let excess liquid drip off.
Dredge each drumstick in the seasoned flour.
Dip the floured chicken back into the buttermilk.
Roll the chicken in breadcrumbs, pressing to adhere the crumbs.
Heat oil in a deep pan over medium-high heat.
Fry the chicken in batches for about 10-12 minutes per side.
Drain on paper towels and let rest for a few minutes before serving.