Preheat your oven to 350°F (175°C) and grease a loaf pan.
In a bowl, whisk together the flour, baking powder, baking soda, and salt.
In another large bowl, cream the softened butter and sugar until light and fluffy.
Add the eggs one at a time, mixing well after each addition.
Stir in the vanilla extract, lemon zest, and lemon juice.
Gradually add the dry ingredients to the wet mixture, stirring until just combined.
Gently fold in the blueberries, being careful not to break them.
Pour the batter into the prepared loaf pan and smooth the top.
Bake for 55-60 minutes or until a toothpick comes out clean.
Allow the bread to cool in the pan for 10 minutes before transferring to a wire rack.