In a mixing bowl, combine ground turkey, breadcrumbs, egg, garlic powder, onion powder, salt, and pepper.
Mix until just combined; avoid overmixing.
Form the mixture into 4 equal patties.
Preheat a grill or skillet over medium heat.
Cook the patties for 5-7 minutes on each side until internal temperature reaches 165°F.
Toast the burger buns on the grill for 1-2 minutes.
Assemble the burgers with lettuce, turkey patty, tomato, and pickles.
Serve immediately and enjoy.